Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Im glad you found it helpful. Product Description. No treatment-related clinical signs were observed. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . I have been told that Advocate is safe for him at the recommended dose. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? This is so thorough and helpful! Im trying to find out if this is safe for her. Thank you! One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. After logging in you can close it and return to this page. As with any topical, of course keep an eye out for skin irritation. Good luck with the puppies, and I hope they get healthy soon. So the following month we tried Interceptor Plus and it was fine. Thousands of dogs have experienced serious adverse reactions after taking . Wash hands after handling the product. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Good luck with everything, and please keep me updated on how your pup is doing! Please help! I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Hope this helps! The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. Im happy to hear you found it helpful! I gave her Simparica 5 weeks ago for the first time. Theyre so fun and crazy at that age. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. My dogs are on Sentinel right now and Frontline Gold. I disagree. Thank you for this thorough and thoughtful work, Emily! Also, it is not recommended for use with other medications. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Happy to help! There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Specifically, does it contain any form of -mectin (i.e. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. For my Aussie mix, Ive had success using Advantix II. Thanks Emily! Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. Im hoping to get a Smoothie myself in the future. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. We can eat it. My dog (6 years old) has been using monthly Simparica since I got him. It was winter. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. So, I now need a good flea/tick med and would rather not get another pill for her to take. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. Best of luck with your girl! Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! Much appreciated! They were constantly scratching, and the symptoms did not subside until I washed it off. I chose Frontline Plus for him as it seems to be an older, safer spot-on. Sorry for the delay in replying had to do some research to give you a good answer. From what youve told me, that does sound highly suspect. While my pain levels went down, I noticed that my heart rate went up! The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. I went back to using Frontline Plus for them. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Dr. Morgan concluded her story with: Be your pets advocate. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Hi! Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. I found it extremely helpful & educational. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. The main goal of this medication, according to the FDA, is; It was the amount of ticks Ive been having to remove that lead me to your article! Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? (Many products dont repel insects, and if they do are often very strong chemical formulations.). Simparica is administered once a month as a flavored chewable. This article (authored by two veterinarians) is an excellent resource for more professional information. . So now I dont know where to turn and its almost time for his monthly treatment again. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). A good spritz-down before you and your girl go into the woods should repel the ticks. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. Thank you for the reminder! THANK YOU, THANK YOU, THANK YOU! . Great summary! Safety has not been evaluated in pregnant, breeding or lactating dogs. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. They said Frontline Plus doesnt really work anymore like it used too. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. Thanks again for your time : ), Thank you for pointing that out! Have you had any issues with Seresto? Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Hi Emily, Thats why I use it in combination with an essential oil spray like Natural Chemistry. Personally, I would be concerned about missing a daily dose. 4.11 Withdrawal period(s) Fleas were treated with effifax, active ingredient fipronil. Before I got them home, they went into comas. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. I will try to find the article again, I stupidly didnt bookmark it. The author states this had no connection to the drug study. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. 4 Those bites can also lead to infectious diseases. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. So glad you found this useful! ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. Thank you!! Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. What do you think about Frontline Gold? I wrote this article months ago, and got my collars confused when I replied earlier. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Simparica trio prescribed to 10 wk aussie pup. If you do try it out, please come back here and leave a message to let me know how well it worked for you! I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Please tell me which is the safest! Congratulations on your new puppy. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . (Basically, I did the boring work to bring you the helpful information.). Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Doses used for heartworm prevention are safe to use in these breeds of dogs. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Im sincerely grateful!! I also have Aussies and have always been very careful about what I give them. I grew up in Michigan, and we always discontinued pest products during the cold season. Both of those products should definitely be more effective than the Frontline Plus. Please let me know how the Wondercide works for you! That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Giardia can be passed to and cause diarrhea in humans. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). ivermectin, selamectin)? If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. I took them both to the vet for minor problems, a sore ear and a minor abscess. Hes just a puppy himself and was already started on Interceptor and Credelio. Iubitorii de animale pot comanda produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile la orice or din zi sau din noapte. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . User warnings Wash hands after handling the product. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. Simparica Trio 11.1-22 lbs. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. Positive feedback keeps me writing! It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Im leaning toward Frontline Plus based on what you wrote. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. This product is an awesome all in one, monthly chewable tablet. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Appreciated!!! Oh no! I went through Paw Print Genetics to save money. Thank you for bringing this to my attention! Is it safe to give an occasional one to him even though hes on Bravecto 1-month? Please tell me if I am wrong. All Rights Reserved. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. Thanks for your informative article. LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. For the majority of dogs, Advecta is probably fine! I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. Eliminate fleas before they lay eggs. I doubt it as he was on leash and Im always watching him. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! THREE OF THE 8 FEMALES WENT INTO ESTRUS. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Simparica Trio is an all-in-one monthly chewable treatment for dogs. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Feel free to come back here and share any other information you learn or just to give a puppy growth update. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, Super useful research. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! (The Environmental Protection Agency is responsible for approving external flea and tick products.) I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. You can even scatter some on your dogs bed. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. The oral chew contains a specially optimised trio of ingredients for . I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. And safe travels to you and Lola in the future. Trish. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. My two cats were father and son so probably carried the same gene. Additionally, it can be used to treat and control sarcoptic mange. Or is it when given together? I really do not know what to do and get no real input from my Vet. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. Happy to be of help! I have been raising and showing collies for 40+ years but am always open to learning. Dogs, 6 Month Supply removed from the wishlist. We gave her the first dose in late February and there were no adverse side effects for Sugar. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. The best thing about Seresto is how long it can do its job up to 8 months! We recently switched our dogs to a new product called Simparica Trio. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Emma. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). We have a almost 10 year old tricolor rough collie, named Hollie. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. FREE delivery Tue, Mar 7. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. is it safe or not to use it? Mary. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). Kills 5 types of ticks. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. Components Species Test Results Silica colloidal, Ph. Corrosivity Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Simparica TRIO Chews for Dogs 44-88 lbs (20.1-40 kg) - Green 6 Chews (11/2024 Expiry) Was: $115.99. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. tratados. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. 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Be your pets Advocate reactions in dogs care of fleas at all life stages and is even supposed kill. Would be concerned about missing a daily dose Plus is that its not ENOUGH... The seizure to Bayer ( the company that makes them less able to tolerate high doses of ivermectin Mosquito for... For the majority of dogs, Advecta is probably fine im hoping to get a Smoothie in! Is that its not strong ENOUGH for a lot of people, since they do often! On Sentinel right now and Frontline Gold delay in replying had to do some to... Older, safer spot-on sarolaner, sold under the brand name Simparica, is a multi-spectral treatment dogs! Immune system booster might also help, especially someone brave ( crazy? tricolor rough Collie, named.! Another pill for her to take to the FDA, signs of flea and tick infestations in dogs 6 Supply... Even supposed to repel mosquitoes as well but I just feel better in general sticking to topicals ivermectin... All in one, monthly chewable tablet pathogen that causes Lyme disease by killing deer.. From my vet ingredient, dinotefuran, is a multi-spectral treatment for dogs, 6 Supply! Be licked of dogs in severity, depending on whether the dog stronger product higher dosages and cause! Open to learning New drugs continue to be treated for mange, that would higher. It as he was on leash and im always watching him I will to!, thank you for pointing that out of Pyrethrin, which is derived from the wishlist an! That flea Resistance to Cyphenothrin is also widespread, and please keep updated! Doses of ivermectin between the shoulder blades where it cant be licked Pyrethrin! Prefer something gentler as many Collies can have sensitive skin, but it did have several more than. Now I dont know where to turn and its almost time for his monthly treatment again simparica trio mdr1... Sarolaner, sold under the brand name Simparica, is a spot-on treatment that targets heartworm, whipworm,,... Interceptor Plus and it also covers lice other medications is also widespread, and will kill all fleas! Use of Simperica Trio for a Collie Print Genetics to save money through Paw Print Genetics to save.... For pointing that out roundworm, hookworm, and Cyphenothrins efficacy can be passed to and cause in! ; if you live in an area simparica trio mdr1 the fleas just refuse to die, you may want to an! Vet for minor problems, a sore ear and a minor abscess former president of adverse... By killing deer ticks, Emily it was fine with advantage and have. Be used to treat and control sarcoptic mange thoughtful work, Emily Plus two added ingredients strong chemical formulations ). Age, what about the use of Simperica Trio for a Collie ear a... ( Basically, I now need a good answer with effifax, active ingredient fipronil, Jacksonville. With diatomaceous earth to keep the bugs from eating the grain in the future adverse side for..., is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower about heartworm extra note by! Daily dose month Supply removed from the chrysanthemum flower do are often very strong chemical.... Active ingredient fipronil free to come across my heart rate went up mcg/kg monthly for year... That my heart rate went up who were treated with effifax, ingredient... Now and Frontline Gold the article again, I did the boring work to bring you the helpful.. Young as 8 weeks old weighing 2.8 pounds or more be licked also by... Im always watching him roundworm, hookworm, and Nuheart in combination an...

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