You might have heard about Dr. David Sinclair on the Joe Rogan Experienceand you are now curious about what does he eat and what supplements he does take. (2006)15Sirtuin activators mimic caloric restriction and delay ageing in metazoans Sinclair et al. Let's be clear: This isn't a clinical trial and the answer is NOT one molecule. This means that it cannot work. Alpha lipoic acid is found naturally in certain food, and when digested, is used in the cells as a cofactor in mitochondrial energy metabolism25Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling Packer et al. Both resveratrol and pterostilbene are classed as natural occurring pstilbenoid compounds. Ive been a big proponent of breathing during exercise-breathing every 20 seconds, says Dr. Sinclair, who adds that he stays in good shape by running three miles every morning. Noting that: Due to the poor aqueous solubility exhibited by resveratrol, digestive absorption is greatly influenced by drug dissolution rate. An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol, Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults, Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans, Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance, Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients, Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients, The Effect of Resveratrol Supplementation on CardioMetabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, DoubleBlind Controlled Trial, Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial, Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease, Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A tripleblind, 6month followup, placebocontrolled, randomized trial, One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease, Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue, Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1, Design and synthesis of compounds that extend yeast replicative lifespan, Sirtuin activators mimic caloric restriction and delay ageing in metazoans, Higher spermidine intake is linked to lower mortality: a prospective population-based study, The positive effect of spermidine in older adults suffering from dementia, The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial, Efficacy of Berberine in Patients with Type 2 Diabetes, Metformin and berberine, two versatile drugs in treatment of common metabolic diseases, A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution, Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES, Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease, The relationship between vitamin K and peripheral arterial disease, Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling, Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction, Andrew Huberman Supplements Full List Deep Dive Into What & Why, David Sinclair Supplements List Deep Dive into What & Why (2023), Rhonda Patrick Supplements List Updated February 2023, Andrew Huberman Book Recommendations 25 He Recommends & Why, Andrew Huberman Diet and Routine What He Eats & Why, Rhonda Patrick Fish Oil Brand Choice & Protocol 2023 Update, $2.48/gram ($62 / 25g) - when using 10% off, $1.84/gram ($184/ 100g) - when buying 4 tubs, $1.86/gram ($85 / 45g) - when using 10% off, $2.70/gram ($324 / 120g) - when buying 4 bottles, Statin a cholesterol lowering prescription drug taken since his early 20s due to family history of cardiovascular disease, Coffee in the morning (once per day), then green tea after that, Intermittent fasting aims to skip at least 1 meal per day. (2014), although more research needed. This may be the case with NR too (because it applies to many supplements), but when David explained this he was explicitly talking about NMN. David also wrote on Reddit in 2020 saying: Micronized resveratrol had better bioavailabilty in humans: Resveratrol options (all micronized) include: Note: Whichever source of trans-resveratrol you take, according to David, you will increase its bio-availability if you take it with a fat source. Greater consumption of specific whole fruits, particularly blueberries, grapes, and apples, was significantly associated with a lower risk of type 2 diabetes, whereas greater fruit juice consumption was associated with a higher risk. He frequently uses a sauna in conjunction with a cold bath. Dr David Sinclair | Sweet Fruit " Darius Behi says: March 29, 2021 at 10:03 pm. Stopped eating deserts at age 40, except for a small taste occasionally, Weight lifting now 3 times per week, was previously just 1 time per week. The first thing to note is that we should be looking for trans-resveratrol, not cis-resveratrol. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. Im big on intermittent fasting and restricting calories, and I think people should not snack-its much better to have your three meals a day, says Dr. Sinclair, who also advocates skipping breakfast. A similar study and result was found a year before also18The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial Wirth et al. We see that the daily dose of 1 gram (800 mg) of wheat germ, actually only contains 1 milligram (mg) of spermidine. RELATED READING: Dr. Rhonda Patricks Fish Oil Protocol & Brand, Dr. Sinclair recommends that people who want to quit smoking should try natural nicotine replacement therapy instead of smoking, which actually increases craving. He is an officer of the Order of Australia (AO).. Sinclair has appeared in Time magazine, The New York Times, The . David Sinclair's work with red-wine compound resveratrol was challenged but ultimately proved right. David discussed this in his podcast with Paul Saladino (see 44mins mark), acknowledging that Niacin derivates (including NR/NMN) require methylation for excretion, but asserting that at this stage the idea of methyl depletion is anecdotal, and not something that has been shown in any NR/NMN studies. Fisetin is typically sold in capsules, which can be taken with food/fat sources, or emptied into yogurt. Any questions or comments, please leave them below. Sinclair eats just once per day, at dinnertime. For foods rich in these, see table 1 in this research paper. The NR Chromadex sell has a patent on it, which reduces competition. The reason isn't exactly known, but thinking evolutionarily, eating stressed plants (i.e., fruit that just made it through a massive drought) allowed our body to sense when the food . The science is further along for NR, but its too early to say which is better for humans. David states in his book that his lab finds: That being said, he isnt against NR, hes just more optimistic on NMN being the better molecule for raising NAD in the long run. Some of our partners may process your data as a part of their legitimate business interest without asking for consent. If you want 14 extra years right off the bat, simply do what many doctors recommend: eat less, exercise regularly, stay away from . Here are the 5 habits: 1. Please note that where I link to products, some of these links are affiliate links. Just saw him on hubermans podcast saying he never has anything to eat in the morning but some olive oil with his supplements for years, then on his own podcast during an add he says he has athletic greens every morning for years. Examples of wheat germ derived spermidine brands: Examples of spermidine trihydrochloride brands: With resveratrol and NMN, for example, the only way to consume them in large quantities, is via supplementation. It is derived from a plant called the French Lilac. Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several. To get closer to the quality that David is likely taking, we can look at research published by an old company of his; Sirtris (who were sold to GSK for $720 million). Specifically, they cause the cell to think its in a nutrient restricted state, and it turns on pathways typically reserved for times of scarcity. Its thought the longevity benefits are at least in part derived from activation of the AMPK cellular pathway. The first is third party testing on the purity of their NMN. The compound could have all the benefits of caloric restriction without the starvation. Davids NMN powder comes from excess product left over from lab experiments. Taking 1 gram of actual spermidine would require consuming 2,000 of their capsules (1 gram = 1,000 milligrams, 1 capsule = 0.5 mg of spermidine). There are some supplements that Dave Sinclair does not recommend either for safety reasons or because they can accelerate aging: David Sinclair runs one to two times per week at fairly high intensity on the Assault Fitness AirRunner. Therefore, the aim of this clinical study was to investigate whether consumption of SRT501, a micronized resveratrol formulation designed by Sirtris, a GSK Company is safe and generates measurable and pharmacologically active levels of parent agent in the circulation and in the liver. He is author of hundreds of peer-reviewed scientific publications. We also recommend resveratrol in powder form by Renue by Science so you can . Covering: We discussed how Nicotinamide Riboside (NR) is an alternative to NMN, How metformin works (noting that its prescription only). He has also been recognized by TIME magazine as one of the top 100 most influential people globally and is an Adjunct Professor of genetics at Harvard Medical School. Due to a family history of high cholesterol, he also takes a statin but it doesn't mean that you need as an anti-aging supplement. Whilst David didnt mention which form he takes it in, the composition of the oil is the same for both. However, if you wanted to be super careful, Dr Charles Brenner (an NAD researcher) mentions elevated homocysteine in the blood can be a sign of lower methyl status so one could get a blood test to check that. Despite being 53 years of age, David looks much younger. For example, he shared on Facebook (link) when his Inside Tracker results showed his vitamin B12 supplementation was causing his B12 levels to get too high. Optimal dosage for treating diabetes can be figured out based on testing the effects on fasting and post-meal blood glucose. His research focuses on epigenetic changes during aging, and the sirtuin-NAD metabolism, including NAD-boosters like NMN . The professor's name is David Sinclair, award-winning scientist and author of the new book Lifespan: . (2010). David is currently working with a lab of about 20 people at Harvard on ways to reverse aging and to better understand the aging process. Sinclair explains that your liver will start making glucose at a steady level after a few weeks, so there won't be large spikes of insulin that put you in a glucose deficit and make you tired. You can search the ~290 comments using the search box at the top of the comments. David has described his yogurt making process as so: David has specifically mentioned Bravo as the brand of yogurt culture he uses, for example at 1:12:28 of his interview on the Ben Greenfield podcast. In a Reddit AMA (link) David was asked whether he would take Berberine if he didnt have access to Metformin. Quercetin Quercetin is a flavonoid contained in many fruits and vegetables like grapes, apples, broccoli, and tomatoes. Sinclair believes that Fisetin is important in fighting to age. In 2008, he sold his company Sirtris, which was developing resveratrol, for $720 million to Glaxo-Smith-Kline. But as you can imagine, it's an unpopular strategy for humanshence the excitement about resveratrol. bucket truck without outriggers; sakura blowjob pictures; movies2watch tv. Rhonda Patrick's General Eating Guidelines Rhonda Patrick's Breakfast Breakfast 1 Eggs Tomatillo Salsa Avocado Oil Mustard Powder Kale Grapefruit Breakfast 2 Cereal Blueberries Pomegranate Flaxseed Coconut Milk Raw Cacao Nibs Hydrolized Collagen Powder Almond Butter Yogurt or VSL #3 Rhonda Patrick on Coffee and Intermittent Fasting That's the takeaway from his book, Lifespan: Why We Ageand Why We Don't Have To, which hit shelves in September. Alternatives to the oven are 1) Wrap your container in a blanket and place it in a warm part of your house. The second is contaminant testing, for things such as heavy metals. Examples of alpha lipoic acid brands are: Also in the podcast with Dave Asprey (link), David says that he takes Coenzyme Q10 because hes taking a statin. Niagen works out approximately $4.44/gram, and NMN starts as low as around $1.80 per gram. Every time you eat fruit, its like eating sugar because the fructose in the fruit turns into glucose very quickly, says Dr. Sinclair, who recommends eating green vegetables and blueberries every day to get the maximum levels of antioxidants in your diet. David mentions leaving it in the oven, which is ok if your oven can maintain this temperature worth checking yours to see if it can do so. This test was presumably InsideTrackers Ultimate product as its the only one that covers all the biomarkers he mentioned. Mark Mattson, a professor of Neuroscience at John Hopkins University, gave a speech at TEDxJohnHopkinsUniversity talking about the extensive benefits of fasting for your brain and body. We're proud to have him on our team as the Chairman of the InsideTracker Scientific Advisory Board. When David visited his family, they let him into a secret Denham had been taking alpha lipoic acid for most of his life, primarily thinking it was an antioxidant. He instills a sense of motivation and positivity in the people who seek his advice and help them improve their health and lead a healthier life without getting exposed to harmful chemicals which can cause damage to our body over time. David Sinclair recommends the following five tips to combat aging and live longer: Rely on senolytics. The goal of this blog is to share information around health and longevity, with the hope that others find it useful. (2018) | The American Journal of Clinical Nutrition: The difference in mortality risk between the top and bottom third of spermidine intakes was similar to that associated with a 5.7 year younger age (95% CI: 3.6, 8.1 y).. Sinclair doesn't go into great detail about what to eat, but does touch on some key points: Eat less meat, eat more plants. If youre not getting much sunlight, then it can be necessary to supplement. Whole fruits are packed with nutrients such as. He didnt however mention the dose that he takes. We and our partners use data for Personalised ads and content, ad and content measurement, audience insights and product development. In terms of timing, he started resveratrol around 2004, and added NMN & Metformin in around 2017/2018. Vitamin K2 on the other hand is found in fermented foods, which are less common in a western diet. David's most recent claim to fame is being named by Time Magazine as one of the World's 100 Most Influential People. (2010). Both compounds can induce gastrointestinal distress, so its common to start off on lower dosages, and gradually increase to the desired amount. Harriet Hall, M.D., reviewed his 2019 anti-aging book at Science-Based Medicine. Sinclair has dropped more than 20 pounds during the COVID pandemic because of this practice, and says he feels fantastic. Very low intake of sugar, bread and pasta. Each group consisted of ten male participants and two female participants. Using these products for healthspan and lifespan benefits is new territory and needs further research. You can imagine, though, that it's not sustainable as a long term solution not only because you'd be constantly hungry but also because you'd be malnourished. I limit calories greatly, but I do exercise every day, he says., RELATED READING: Dr. Peter Attias Supplement List, Biohacking Toolkit, & Diet, We all have a certain percentage of fat in our body, and we also have some sugar thats stored in the liver. RELATED READING: Dr. Andrew Hubermans Time-Restricted Diet, Im a big proponent of the view that we seem to be getting more and more people focused on these high-tech anti-aging treatments, says Dr. Sinclair. However, on the latest interview with Joe Rogan, they discussed a 2018 paper which showed metformin inhibits mitochondrial adaptations to aerobic exercise training. David explained that this makes sense, and its exactly metformins inhibition of mitochondrial function that leads to some of the health benefits. The consent submitted will only be used for data processing originating from this website. He eats little meat, preferring foods rich with nutrients, enzymes, and fiber; in particular fruits, vegetables, nuts, and seeds. However, there isnt yet research on optimal dosage for someone with already healthy blood glucose levels. Eating a Healthy Diet. No specific details are available at the moment. Fast intermittently. Typically doctors only prescribe Metformin for blood sugar control issues (type 2 diabetes). 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