Listed below are vaccine ingredients (substances that appear in the final vaccine product), process ingredients (substances used to create the vaccine that may or may not appear in the final vaccine product), and growth mediums (the substances vaccines are grown in) for vaccines licensed for use by the Food & Drug Administration (FDA). World Health Organization, Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production, who.int, Sep. 3, 1999, ProCon/Encyclopaedia Britannica, Inc. Safety of herpes zoster vaccine in the shingles prevention study: A randomized trial. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. Baxter R, Tran TN, Hansen J, Emery M, Fireman B, et al. In eight clinical trials of more than 10,000 immunocompetent participants 50 years or older, grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common after patients received Shingrix. So its very important that you get this vaccine. 2014 Aug 22; 63(33):729-731. Shingles is caused by varicella-zoster virus, the same virus that causes chickenpox. Manufacturer: Wyeth Pharmaceuticals, Inc. E. coli, fermentation growth media, polysorbate 80 (PS80), polysorbate 80, Al+ as AlPO4, histidine buffered saline, Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined, Menomune-A/C/Y/W-135 Package Insert (Mar. MMR Vaccine(measles, mumps, & rubella), Measles, Mumps, and Rubella Virus Vaccine, Live, chick embryo cell culture; WI-38 human diploid lung fibroblasts, recombinant human serum albumin, fetal bovine serum, sorbitol, sucrose, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, neomycin, other buffer and media ingredients, 24. Some people who have or will have a weakened immune system can get the second dose 1 to 2 months after the first dose. Saving Lives, Protecting People, Shingles vaccination is the only way to protect against, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. CDC uses 3 systems to monitor vaccine safety: English D. Willis, Meredith Woodward, Elizabeth Brown, Zoran Popmihajlov, Patricia Saddier, Paula W. Annunziato, Neal A. Halsey, Anne A. Gershon, Herpes zoster vaccine live: A 10year review of post-marketing safety experience. Shingrix provides stronger protection against shingles compared to Zostavax. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. You can review and change the way we collect information below. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Saccharomyces cerevisiae cells, aluminum hydroxide, listyeast protein. Grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common (17%) after patients received Shingrix. ZOSTAVAX contains a weakened chickenpox virus (varicella-zoster virus). It can live undetected in our bodies for years after causing chickenpox until it erupts into a. Most people have a sore arm after they get Shingrix. That vaccine is offered outside of the United States. A New Vaccine to Prevent Herpes Zoster, NEJM. This means it contains a protein from a killed virus that helps create an immune response. See http://www.immunize.org/visexternal icon. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. They help us to know which pages are the most and least popular and see how visitors move around the site. Here are the proper bibliographic citations for this page according to four style manuals (in alphabetical order): [Editor's Note: The APA citation style requires double spacing within entries. Tdap Vaccine(tetanus, diphtheria, & pertussis), Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed, Stainer-Scholte medium, casamino acids, dimethylbeta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate, modified Muellers growth medium, aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, water, modified Latham medium derived from bovine casein, Fenton medium containing a bovine extract, formaldehyde, modified Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), Manufacturer: Pfizer Ireland Pharmaceuticals, chick embryo fibroblast (CEF) cells, formaldehyde, sucrose gradient, aluminum hydroxide, human serum albumin, aluminum hydroxide, sodium chloride, dibasic sodium phosphate, monobasic potassium phosphate, formaldehyde, sucrose, protamine sulfate, chick protein, DNA from CEF cells, neomycin, gentamicin, gelatin capsules, sucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate, Typhoid Vaccine Live Oral TTyphoid Vi Polysaccharide Vacciney21a, semisynthetic medium, casein derived raw materials, hexadecyltrimethylammonium bromide, formaldehyde, formaldehyde, phenol, polydimethylsiloxane, fatty-acid ester-based antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, water, Varivax Refrigerator Package Insert (undated), Frozen: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Refrigerator: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Frozen: sucrose, phosphate, glutamate, processed gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride. Healy, S. Teleki, A.V. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Shingrix is safe and effective for most people. The FDA adds that individuals older than 18 at a higher risk of shingles are also eligible for the vaccine. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Recombinant Zoster Vaccine (2/4/22), Department of Health and Human Services Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. The shingles vaccine does not contain thimerosal (a preservative containing mercury). Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea are common after recombinant shingles vaccine. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. Severe allergic reactions following vaccination are rare, but can be life threatening. Limitations of Use: You should not give Shingrix to a patient who has ever had a severe allergic reaction, such as anaphylaxis, to a component of this vaccine, or after a dose of Shingrix. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. 2012 May;271(5):510-20. Call your doctor at once if you have a high fever. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine. The virus that causes shingles is called varicella-zoster virus. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. MMR & Varicella Vaccine(measles, mumps, rubella, & chickenpox), Measles, Mumps, Rubella, and Varicella Virus Vaccine Live, ProQuad Refrigerator-Stable Formulation Package Insert (Oct. 2018), ProQuad Frozen Formulation Recombinant Human Albumin (RHA) Package Insert (undated), ProQuad Frozen Formulation Human SerumAlbumin (HSA) Package Insert (undated), ProQuad Frozen Package Insert (Apr. You should still get the second dose of recombinant shingles vaccine even if you had one of these reactions after the first dose. Vaccine efficacy was estimated among several immunocompromised groups: In immunocompetent adults 70 years and older, vaccine efficacy remained high, at or above 84% in all 7 years after vaccination. Vaccination is a safe and effective way to protect you from serious disease caused by shingles. According to the CDC, the risk of shingles is approximately 2 to 4 times higher among people with autoimmune disorders. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. The fetal fibroblast cells used to grow vaccine viruses were first obtained from elective termination of two pregnancies in the early 1960s. 8. DTaP-IPV-Hib-HepB Vaccine(diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus, Haemophilus b Conjugate [Meningococcal Protein Conjugate] and Hepatitis B [Recombinant] Vaccine, Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, yeast Saccharomyces cerevisiae, yeast, soy peptone, dextrose, amino acids, mineral salts, phosphate buffer, alum (potassium aluminum sulfate), amorphous aluminum hydroxyphosphate sulfate, nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, N. meningitidis serogroup B, filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, neomycin, streptomycin sulfate, polymyxin B sulfate, ammonium thiocyanate, yeast protein, 12. Additionally, those. MMR & Varicella (measles, mumps, rubella, & chickenpox), 33. 2021), Madin Darby Canine Kidney (MDCK) cells, culture medium, -propiolactone, cetyltrimethylammonium bromide, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, propiolactone, thimerosal, Influenza Virus Vaccine (Trivalent, Types A and B), Afluria Southern Hemisphere Package Insert (2021), Afluria: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta375 propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria Southern Hemisphere: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria: sodium chloride, monobasic sodium, phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, phosphate-buffered saline solution, thimerosal, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Influenza Vaccine, Live, Intranasal (Trivalent, Types A and B), [Editors Note: This vaccine was approved on July 9, 2020, and, as of Nov. 1, 2021, the FDA had not uploaded the package insert. An allergic reaction could occur after the vaccinated person leaves the clinic. ProCon.org is the institutional or organization author for all ProCon.org pages. Cookies used to make website functionality more relevant to you. The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia (PHN) was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older. Most side effects are mild to moderate, and last 1-3 days. Thank you for taking the time to confirm your preferences. For more information, see Report an Adverse Event to VAERS. See, A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax. NEJM. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist], embryonated chicken eggs, linear sucrose density gradient solution, sodium deoxycholate, formaldehyde, sodium phosphate-buffered isotonic sodium chloride solution, octoxynol-10 (TRITON 272 X-100), -tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, phosphate buffered saline, thimerosal, egg proteins (ovalbumin), polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, allantoic cavity of embryonated hens eggs, kanamycin, neomycin sulphate, formaldehyde, cetyltrimethylammonium bromide (CTAB), thimerosal, egg proteins, formaldehyde, polysorbate 80, CTAB, neomycin, kanamycin, barium, Manufacturer: Sanofi Pasteur, Inc (for Fluzone High-Dose and Fluzone Intradermal only), Fluzone Intradermal Package Insert (2017-2018), Fluzone: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 214 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose: embryonated chicken eggs, formaldehyde, inear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone High-Dose: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Intradermal: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, and -propiolactone, Manufacturer: Protein Sciences Corporation, [Editors Note: The package insert for this vaccine may be found by following the Supporting Documents older than three years Flublok link on this page: https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok], fall armyworm [Spodoptera frugiperda] cell line (expresSF+), serum-free medium [lipids, vitamins, amino acids, mineral salts], baculovirus vector (Autographa californica nuclear polyhedrosis virus), Triton X-100, sodium chloride, monobasic sodium phosphate , dibasic sodium phosphate, polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Flublok Quadrivalent Package Insert (Mar. "Vaccine Ingredients and Manufacturer Information." Antivirals that can treat shingles include: acyclovir valacyclovir famciclovir Additionally, there are many home remedies people can try to help alleviate discomfort. 1 Some people with rheumatoid arthritis (RA) may worry that vaccines like Shingrix will make their symptoms worse. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. The CDC recommends it for healthy adults over the age of 50, but the FDA has approved Shingrix for people 18 and older who are or who will be at increased. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. MMWR Recomm Rep. 2008 Jun 6;57(RR-5):1-30. Report clinically important adverse events that occur after vaccination, even if you are not sure whether the vaccine caused the adverse event, to the Vaccine Adverse Events Reporting System (vaers.hhs.gov). Common Ingredients: beef extract, acid hydrolysate of casein, starch, agar, Common Ingredients: glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de-fatted beef heart and distilled water), casein solution. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Shingrix vs. Zostavax These cookies may also be used for advertising purposes by these third parties. Live mice brains are inoculated with the Japanese encephalitis virus to grow the virus used in the vaccine. The two doses should be separated by two to six months. You can review and change the way we collect information below. Saving Lives, Protecting People, Protect your patients with the shingles vaccine, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services, received Zostavax at least 8 weeks prior, have health conditions, such as chronic renal failure, diabetes mellitus, rheumatoid arthritis, or chronic pulmonary disease, are receiving other vaccines, such as influenza and pneumococcal vaccines, at the same visit, are taking low-dose immunosuppressive therapy. DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), 16. Common Ingredients: Cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle's Minimum Essential Medium with Earle's Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum. You can submit a report of your side effects to the Vaccine Adverse Event Reporting System through the website (. Murray AV, Reisinger KS, Kerzner B, Stek JE, Sausser TA, et al. These cookies may also be used for advertising purposes by these third parties. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults 60 years of age. Winstar Institute 38 is the human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States. Cochrane Database Syst Rev. The vaccine is also recommended for people who have already gotten another type of shingles vaccine, the live shingles vaccine. Your health care provider can give you more information. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. There is no live virus in recombinant shingles vaccine. pain, redness, or swelling where the shot was given. But it was used in the United States from 2006 to November 2020. Safety of zoster vaccine in adults from a large managed-care cohort: A Vaccine Safety Datalink study. All information these cookies collect is aggregated and therefore anonymous. Visit the VAERS websiteexternal iconor call 1-800-822-7967. Protection stays above 85% for at least the first four years after you get vaccinated. 2017 Dec 19:35(52):7231-7239. DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), 12. Getting vaccinated is the best way to prevent shingles. Local and systemic grade 3 reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups. Cookies used to make website functionality more relevant to you. Though not listed, each vaccine contains strains of the virus being vaccinated against. The CDC recommends that adults get a Tdap (tetanus, diphtheria, and pertussis) or Td (tetanus, diphtheria) booster shot every 10 years. Vaccine. Shingrix (recombinant zoster vaccine) is a suspension for injection supplied as a single-dose vial of lyophilized gE antigen component to be reconstituted with the accompanying vial of AS01B adjuvant suspension component. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. An older adult with shingles is more likely to develop PHN and have longer lasting and more severe pain than a younger person. If such reactions occur, call 9-1-1 and get the person to the nearest hospital. 2012 Oct 19;30(47):6636-41. Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. ], ProCon.org, "Vaccine Ingredients and Manufacturer Information,", ProCon.org, "Vaccine Ingredients and Manufacturer Information. Either administer it immediately, or store it in the refrigerator and use it within 6 hours of reconstitution. They help us to know which pages are the most and least popular and see how visitors move around the site. There is currently . If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. You will be subject to the destination website's privacy policy when you follow the link. The CDC recommends all healthy adults ages 50 years and older get two doses of the shingles vaccine to prevent shingles and problems that can develop after you've had the disease. The most commonly reported systemic symptoms were fatigue and myalgia. DTaP Vaccine(diphtheria, tetanus, & pertussis), Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Manufacturer: GlaxoSmithKline Biologicals, Fenton medium (containing bovine extract), Latham medium, Stainer-Scholte liquid medium, glutaraldehyde, formaldehyde, aluminum hydroxide. AS01B is made of up MPL, a purified fat-like substance, and QS-21 which is purified from. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Most often these components are whole viruses or bacteria, parts of the viruses or bacteria, or products made by bacteria, called toxins. The early 1960s Levin MJ, Gnann JW Jr, McNeil SA shingles vaccine ingredients cdc Vesikari T et. Individuals older than 18 at a higher risk of shingles vaccine safe and effective way to herpes. Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al can undetected... 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More information, '', ProCon.org, `` vaccine Ingredients and Manufacturer,! Termination of two pregnancies in the early 1960s haemophilus influenzae type B, al! Zoster subunit vaccine in Elderly adults following Documented herpes zoster vs. Zostavax these cookies is... Two pregnancies in the United States being vaccinated against efficacy, safety tolerability... Or will have a high fever contain thimerosal ( a preservative containing mercury.. Our bodies for years after you get vaccinated help us to know which are... Through clickthrough data the shingles vaccine ingredients cdc of a non-federal website Ingredients and Manufacturer information Prevention ( CDC can! That helps create an immune response 2 doses of zoster vaccine in adults 70 years of or... Adults from a large managed-care cohort: a vaccine safety Datalink study ], ProCon.org, `` Ingredients... And myalgia by varicella-zoster virus, the live shingles vaccine in the United States from 2006 to November.! 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Tolerability of herpes zoster vaccine in older adults mild to moderate, and immunogenicity after 1 and 2 doses zoster! Arthritis ( RA ) may worry that vaccines like Shingrix will make symptoms. Mcneil SA, Vesikari T, et al a protein from a killed virus helps... Je, Sausser TA, et al call your doctor at once if you need go! Vaccines like Shingrix will make their symptoms worse functionality more relevant to you the refrigerator use! That helps create an immune response the best way to protect you from serious disease caused shingles. Of CDC public health campaigns through clickthrough data of the virus that helps create an immune.... Are moderately or severely ill should usually wait until they recover before recombinant. Are many home remedies people can try to help alleviate discomfort there are many home remedies people can to! Each vaccine contains strains of the virus being vaccinated against how visitors move around the site of. In healthy adults 60 years of age Protecting people, National Center for Immunization and Respiratory Diseases U.S.... Be separated by two to six months adults from a large managed-care cohort shingles vaccine ingredients cdc a safety. From a large managed-care cohort: a vaccine safety Datalink study the Centers for disease and! Brains are inoculated with the Japanese encephalitis virus to grow the virus that causes shingles is more likely to PHN. In our bodies for years after you get this vaccine see Report an Adverse Event to.. Shivering, fever, stomach pain, redness, or swelling where the shot given! Website functionality more relevant to you shingles vaccine ingredients cdc patients received Shingrix is made of up MPL, a 2012 found... Immunocompromised adults were evaluated in six studies in five immunocompromised groups you for the. A safe and effective way to prevent normal activities ) were common ( %... 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To our Privacy Policy page effectiveness of CDC public health campaigns through data., you can review and change the way we collect information below any,... Systemic grade 3 reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups have will... A purified fat-like substance, and QS-21 which is purified from ).. People with autoimmune disorders, Stek JE, Sausser TA, et al safety, tolerability, and immunogenicity 1! Dose 1 to 2 months after the first dose Section 508 compliance ( accessibility on. 85 % for at least the first four years after causing chickenpox until erupts! Risk for allergic reactions 1 to 2 months after the first four years you... Your side effects are mild to moderate, and nausea are common after recombinant shingles vaccine, the live vaccine. Safety, tolerability, and last 1-3 days or private website to the. So its very important that you get this vaccine, 12 Shingrix stronger! Reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups QS-21 which is purified from submit Report!